Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565555 | 1.00 | P4HTM (0.50) | P4HTMRAB9AHCAR2HDAC3TNKS | |
| SCHEMBL1124232 | 0.81 | P4HTM (0.50) | P4HTMRAB9AHCAR2HDAC3TNKS | |
| SCHEMBL1124233 | 0.81 | P4HTM (0.50) | P4HTMRAB9AHCAR2HDAC3TNKS | |
| SCHEMBL24925531 | 0.81 | HDAC1 (0.49) | RAB9AHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1124047 | 0.79 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC3TNKS | |
| SCHEMBL1124046 | 0.79 | P4HTM (0.55) | P4HTMRAB9AHCAR2HDAC3TNKS | |
| SCHEMBL10414574 | 0.78 | CA12 (0.54) | RAB9AHCAR2CA12CA1CA2 | |
| SCHEMBL10414576 | 0.78 | CA12 (0.54) | RAB9AHCAR2CA12CA1CA2 | |
| SCHEMBL3780465 | 0.77 | P4HTM (0.58) | P4HTMRAB9AHCAR2HDAC3TNKS | |
| SCHEMBL3780462 | 0.77 | P4HTM (0.58) | P4HTMRAB9AHCAR2HDAC3TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173424-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000066566-A1 | PYRIMIDINE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |
| US-4898968-A | INSECTICIDES, MITICIDES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-02-06 | — | — | US | disclosed |
| US-4760143-A | Contining pyrimidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-07-26 | — | — | US | disclosed |
| US-4661488-A | Pyrimidine substituted-2,2-dimethylcyclopropane carboxylates useful for combating insect and acarine pests at a locus | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-04-28 | — | — | US | disclosed |
| EP-0162538-A2 | Cyclopropane derivates | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-11-27 | — | — | EP | disclosed |