Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 19/20 | 0.74 |
| ▸ | EDNRB | P24530 | 10/20 | 0.66 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.63 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.63 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.63 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.63 |
| ▸ | DHPS | P49366 | 1/20 | 0.63 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.63 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7565809 | 0.86 | EDNRA (0.77) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL8444262 | 0.86 | EDNRA (0.77) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL8444260 | 0.86 | EDNRA (0.77) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7567459 | 0.86 | EDNRA (0.77) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7568395 | 0.85 | EDNRA (0.73) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7567784 | 0.85 | EDNRA (0.59) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7567986 | 0.83 | EDNRA (0.71) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7575460 | 0.82 | EDNRA (0.74) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7573822 | 0.82 | EDNRA (0.72) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7567876 | 0.82 | EDNRA (0.70) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | claimed |
| US-5962682-A | Aryl- and hetaryl-sulfonamide derivatives, their preparation and their use as endothelin antagonists | HOFFMANN-LA ROCHE INC. (US) | 1999-10-05 | — | — | US | disclosed |