Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7573656 | 0.93 | EDNRB (0.56) | EDNRBALDH1A1MAPTGAAALOX15 | |
| SCHEMBL7570795 | 0.90 | EDNRB (0.59) | EDNRBALDH1A1MAPTGAAALOX15 | |
| SCHEMBL7565610 | 0.88 | EDNRB (0.57) | EDNRBALDH1A1HTTLMNATSHR | |
| SCHEMBL7567507 | 0.83 | EDNRB (0.66) | EDNRBALDH1A1MAPTMAPK1LMNA | |
| SCHEMBL7572798 | 0.83 | EDNRB (0.64) | EDNRBALDH1A1MAPTGAAALOX15 | |
| SCHEMBL7569450 | 0.82 | EDNRB (0.53) | EDNRBALDH1A1MAPTHTTLMNA | |
| SCHEMBL7568095 | 0.79 | EDNRB (0.81) | EDNRBALDH1A1MAPTTDP1LMNA | |
| SCHEMBL7567416 | 0.78 | EDNRB (0.70) | EDNRBALDH1A1GAAHTTLMNA | |
| SCHEMBL7566571 | 0.76 | EDNRB (0.56) | EDNRBALDH1A1MAPTMAPK1HTT | |
| SCHEMBL7569419 | 0.76 | EDNRB (0.54) | EDNRBALDH1A1MAPTGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |