Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 17/20 | 0.79 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL756603 | 1.00 | GRM2 (0.79) | GRM2ALOX5KCNH2 | |
| SCHEMBL12569370 | 0.92 | GRM2 (0.77) | GRM2ALOX5KCNH2 | |
| SCHEMBL759263 | 0.90 | GRM2 (0.77) | GRM2ALOX5KCNH2 | |
| SCHEMBL759142 | 0.90 | GRM2 (0.77) | GRM2ALOX5KCNH2 | |
| SCHEMBL756214 | 0.90 | GRM2 (0.79) | GRM2ALOX5KCNH2 | |
| SCHEMBL758501 | 0.90 | GRM2 (0.77) | GRM2ALOX5KCNH2 | |
| SCHEMBL756794 | 0.90 | GRM2 (0.79) | GRM2ALOX5KCNH2 | |
| SCHEMBL758794 | 0.90 | GRM2 (0.77) | GRM2ALOX5KCNH2 | |
| SCHEMBL756730 | 0.89 | GRM2 (0.75) | GRM2ALOX5KCNH2 | |
| SCHEMBL757750 | 0.89 | GRM2 (0.75) | GRM2ALOX5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118093-B1 | [1,2,3]TRIAZOLYL SUBSTITUTED QUINOLINES AND COUMARINS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK CANADA INC (CA) | 2012-03-21 | — | — | EP | disclosed |
| US-7960409-B2 | e.g. 4-(3-fluorophenyl)-7-({4-[1-hydroxy-1-(trifluoromethyl)propyl]-1H-1,2,3-triazol-1-yl}methyl)-2H-chromen-2-one; leukotriene biosynthesis and 5-lipoxygenase (5-LO); inhibitor; antiatherosclerotic, antiasthmatic, antiallergic, antiinflammatory and cytoprotective agents | MERCK SHARP & DOHME CORP. (US) | 2011-06-14 | — | — | US | disclosed |