Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765898 | 1.00 | BACE1 (0.47) | BACE1 | |
| SCHEMBL759014 | 1.00 | BACE1 (0.47) | BACE1 | |
| SCHEMBL756977 | 1.00 | BACE1 (0.47) | BACE1 | |
| SCHEMBL756995 | 0.84 | BACE1 (0.47) | BACE1 | |
| Hydrochloric Acid SCHEMBL5616450 | 0.83 | BACE1 (0.46) | BACE1 | |
| Hydrochloric Acid SCHEMBL760111 | 0.83 | BACE1 (0.46) | BACE1 | |
| Hydrochloric Acid SCHEMBL761491 | 0.83 | BACE1 (0.46) | BACE1 | |
| SCHEMBL764637 | 0.83 | BACE1 (0.47) | BACE1 | |
| SCHEMBL754907 | 0.83 | BACE1 (0.47) | BACE1 | |
| SCHEMBL755104 | 0.82 | BACE1 (0.55) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211904-B2 | Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease | Merck, Sharp & Dohme Corp. (US) | 2012-07-03 | — | — | US | disclosed |
| EP-1910364-B1 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-03-21 | — | — | EP | disclosed |