Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.42 |
| ▸ | EDNRB | P24530 | 4/20 | 0.37 |
| ▸ | GLRA3 | O75311 | 2/20 | 0.35 |
| ▸ | GLRB | P48167 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | DHPS | P49366 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570858 | 0.81 | EDNRA (0.48) | EDNRAEDNRBPOLBALDH1A1 | |
| SCHEMBL7567975 | 0.80 | EDNRA (0.55) | EDNRAEDNRBGLRA3GLRBALDH1A1 | |
| SCHEMBL7567961 | 0.80 | EDNRA (0.55) | EDNRAEDNRBGLRA3GLRBPOLB | |
| SCHEMBL7570509 | 0.78 | EDNRA (0.49) | EDNRAEDNRBPOLBALDH1A1SMN1; SMN2 | |
| SCHEMBL7569569 | 0.78 | EDNRA (0.52) | EDNRAEDNRBALDH1A1USP2HSP90AA1 | |
| SCHEMBL7567923 | 0.78 | EDNRA (0.52) | EDNRAEDNRBGLRA3GLRBALDH1A1 | |
| SCHEMBL7567596 | 0.76 | EDNRA (0.50) | EDNRAEDNRBGLRA3GLRBALDH1A1 | |
| SCHEMBL7567694 | 0.73 | EDNRA (0.60) | EDNRAEDNRB | |
| SCHEMBL7568711 | 0.71 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL7569450 | 0.71 | EDNRB (0.53) | EDNRAEDNRBALDH1A1MAPTABCC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |