Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP1 | P63208 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012386 | 0.89 | ACACB (0.48) | CKS1BSKP1SKP2MAPTNPSR1 | |
| SCHEMBL31271217 | 0.88 | BTK (0.54) | CKS1BSKP1SKP2PDE10AACACB | |
| SCHEMBL15022923 | 0.86 | CKS1B (0.55) | CKS1BSKP1SKP2PDE10AJAK3 | |
| SCHEMBL6140015 | 0.86 | CKS1B (0.56) | CKS1BSKP1SKP2MAPTNPSR1 | |
| SCHEMBL3935766 | 0.84 | P2RY12 (0.63) | P2RY12 | |
| SCHEMBL21564356 | 0.83 | CKS1B (0.55) | CKS1BSKP1SKP2PDE10AJAK3 | |
| SCHEMBL381643 | 0.82 | CKS1B (0.48) | CKS1BSKP1SKP2MAPTNPSR1 | |
| SCHEMBL3281737 | 0.82 | DPP4 (0.50) | CKS1BSKP1SKP2MAPTNPSR1 | |
| SCHEMBL23339865 | 0.82 | CKS1B (0.54) | CKS1BSKP1SKP2PDE10AJAK3 | |
| SCHEMBL16197180 | 0.82 | CKS1B (0.54) | CKS1BSKP1SKP2PDE10AJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9969744-B2 | Compounds for use in cognition improvement | FUNDACIÓN LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2018-05-15 | — | — | US | disclosed |
| US-20170217973-A1 | NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2017-08-03 | — | — | US | disclosed |
| US-9636341-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2017-05-02 | — | — | US | disclosed |
| EP-2961741-B1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | FUND PARA LA INVESTIG MEDICA APLICADA (ES) | 2017-04-05 | — | — | EP | disclosed |
| US-9573956-B2 | Compounds as dual inhibitors of phosphodiesterases and histone deacetylases | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2017-02-21 | — | — | US | disclosed |
| US-20160002246-A1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA (ES) | 2016-01-07 | — | — | US | disclosed |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-03 | — | — | US | disclosed |
| US-9150543-B2 | Substituted indolyl alkyl amino derivatives as inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N. V. (BE) | 2015-10-06 | — | — | US | disclosed |
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-10-16 | — | — | US | disclosed |
| US-8524728-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-09-03 | — | — | US | disclosed |
| US-20120157456-A1 | SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-06-21 | — | — | US | disclosed |
| US-8193205-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-06-05 | — | — | US | disclosed |
| US-8193205-B2 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-06-05 | — | — | US | disclosed |
| US-8138198-B2 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | ANGIBAUD PATRICK RENE (FR) | 2012-03-20 | — | — | US | disclosed |
| US-8138198-B2 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | ANGIBAUD PATRICK RENE (FR) | 2012-03-20 | — | — | US | disclosed |
| US-20110136841-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | VERDONCK MARC GUSTAAF CELINE | 2011-06-09 | — | — | US | disclosed |
| US-20090221580-A1 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | ANGIBAUD PATRICK RENE | 2009-09-03 | — | — | US | disclosed |
| US-20090221580-A1 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | ANGIBAUD PATRICK RENE | 2009-09-03 | — | — | US | disclosed |
| US-20090124646-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-14 | — | — | US | disclosed |
| US-20090124646-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221580-A1 | Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase | HDAC1, HDAC2, HDAC3 | CKS1B 402/4885SKP1 613/4885SKP2 595/4885 |
| US-20090124646-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | CKS1B 225/4885SKP1 1527/4885SKP2 594/4885 |
| US-20170217973-A1 | NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT | CHAT, NLN, GRIN2C | CKS1B 1326/4885SKP1 2956/4885SKP2 914/4885 |
| US-20120157456-A1 | SUBSTITUTED AMINOPROPENYL PIPERIDINE OR MORPHOLINE DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC2, HDAC3 | CKS1B 402/4885SKP1 613/4885SKP2 595/4885 |
| US-20140309248-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | CKS1B 246/4885SKP1 1464/4885SKP2 634/4885 |
| US-20110136841-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | CKS1B 225/4885SKP1 1527/4885SKP2 594/4885 |
| US-20150342950-A1 | SUBSTITUTED INDOLYL ALKYL AMINO DERIVATIVES AS NOVEL INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC3, HDAC2 | CKS1B 225/4885SKP1 1527/4885SKP2 594/4885 |
| US-20160002246-A1 | NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES | PDE1A, HDAC1, HDAC2 | CKS1B 608/4885SKP1 1340/4885SKP2 2431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.