Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7001422 | 0.87 | CYP1A2 (0.54) | SMN1; SMN2HPGDMEN1KMT2ATAAR1 | |
| SCHEMBL7001340 | 0.85 | SMN1; SMN2 (0.49) | SMN1; SMN2HPGDMEN1KMT2ATAAR1 | |
| SCHEMBL7833557 | 0.81 | GAA (0.48) | SMN1; SMN2HPGDMEN1KMT2ATAAR1 | |
| SCHEMBL30689125 | 0.81 | GAA (0.75) | HPGDGAALMNAL3MBTL1HDAC1 | |
| SCHEMBL10411168 | 0.80 | MCHR1 (0.50) | MEN1KMT2ARECQLCYP1A2CYP2D6 | |
| SCHEMBL25361633 | 0.80 | TAAR1 (0.73) | SMN1; SMN2HPGDMEN1KMT2ATAAR1 | |
| Water SCHEMBL10995055 | 0.79 | MCHR1 (0.49) | MEN1KMT2ARECQLCYP1A2CYP2D6 | |
| SCHEMBL17621160 | 0.79 | HPGD (0.94) | SMN1; SMN2HPGDMEN1KMT2ATAAR1 | |
| SCHEMBL9324770 | 0.78 | RECQL (0.59) | SMN1; SMN2HPGDMEN1KMT2ATAAR1 | |
| Oxalic Acid SCHEMBL10997253 | 0.78 | MCHR1 (0.48) | SMN1; SMN2MEN1KMT2ARECQLCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1127051-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2001-08-29 | — | — | EP | claimed |
| WO-2000027822-A2 | TRICYCLIC PYRAZOLE DERIVATIVES | BASF AKTIENGESELLSCHAFT (DE) | 2000-05-18 | — | — | WO | claimed |
| EP-1165544-A1 | SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE | BASF AKTIENGESELLSCHAFT (DE) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059901-A1 | SUBSTITUTED 1,4-DIHYDROINDENO[1,2-C]PYRAZOLES AS INHIBITORS OF TYROSINE KINASE | KNOLL GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2000-10-12 | — | — | WO | disclosed |