Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 17/20 | 0.56 |
| ▸ | EDNRB | P24530 | 15/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7570365 | 0.95 | EDNRA (0.56) | EDNRAEDNRBKDM4EALDH1A1 | |
| SCHEMBL7565948 | 0.91 | EDNRB (0.57) | EDNRAEDNRB | |
| SCHEMBL7568053 | 0.89 | EDNRA (0.56) | EDNRAEDNRB | |
| SCHEMBL7575456 | 0.86 | EDNRA (0.58) | EDNRAEDNRB | |
| SCHEMBL7567616 | 0.85 | EDNRA (0.57) | EDNRAEDNRB | |
| SCHEMBL7566613 | 0.84 | EDNRA (0.58) | EDNRAEDNRBKDM4EALDH1A1 | |
| SCHEMBL7570825 | 0.84 | EDNRB (0.62) | EDNRAEDNRB | |
| SCHEMBL8321995 | 0.84 | EDNRA (0.65) | EDNRAEDNRB | |
| SCHEMBL7570867 | 0.84 | EDNRA (0.67) | EDNRAEDNRB | |
| SCHEMBL7566513 | 0.83 | EDNRA (0.65) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799206-B1 | ARYL- AND HETARYL-SULFONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ENDOTHELIN ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2002-09-11 | — | — | EP | claimed |