Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21097283 | 0.94 | GAA (0.50) | GAAHTR2ABCL9CTNNB1MGLL | |
| SCHEMBL20606380 | 0.85 | HTR2A (0.47) | GAAHTR2ABCL9CTNNB1MGLL | |
| SCHEMBL21058173 | 0.85 | GAA (0.46) | GAAHTR2ABCL9CTNNB1MGLL | |
| SCHEMBL20625250 | 0.83 | GAA (0.51) | GAAHTR2ABCL9CTNNB1MGLL | |
| SCHEMBL31640376 | 0.80 | MAPT (0.46) | GAAHTR2ABCL9CTNNB1MGLL | |
| SCHEMBL2722317 | 0.80 | CYP1A2 (0.49) | GAAHTR2ABCL9CTNNB1ALDH1A1 | |
| SCHEMBL2803614 | 0.80 | CYP1A2 (0.49) | GAAHTR2ABCL9CTNNB1ALDH1A1 | |
| SCHEMBL6552747 | 0.80 | EPHX2 (0.45) | GAABCL9CTNNB1ALDH1A1TDP1 | |
| SCHEMBL12653859 | 0.79 | POLB (0.48) | GAAHTR2ABCL9CTNNB1MGLL | |
| SCHEMBL1560458 | 0.79 | CYP1A2 (0.51) | GAAHTR2ABCL9CTNNB1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1158982-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2002-06-12 | — | — | EP | disclosed |
| EP-1158982-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000052134-A2 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-09-08 | — | — | WO | disclosed |