Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 12/20 | 0.51 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.51 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | KIF5B | P33176 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.48 |
| ▸ | CSK | P41240 | 1/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14564693 | 0.87 | KDR (0.60) | EGFRKDRRETKIF5BFGFR1 | |
| SCHEMBL14564692 | 0.86 | KDR (0.61) | EGFRKDREPHA2RETKIF5B | |
| Hydrochloric Acid SCHEMBL7581670 | 0.86 | EGFR (0.63) | EGFRSRCRIPK2NOD1AURKA | |
| SCHEMBL3677434 | 0.85 | KDR (0.61) | EGFRSRCAURKAKDREPHB4 | |
| SCHEMBL3672100 | 0.85 | KDR (0.61) | EGFRSRCAURKAKDREPHB4 | |
| SCHEMBL3675120 | 0.84 | KDR (0.48) | EGFRSRCAURKAKDREPHB4 | |
| SCHEMBL5219211 | 0.84 | ENPP1 (0.49) | EGFRAURKAKDREPHB4EPHA2 | |
| SCHEMBL3673766 | 0.84 | KDR (0.62) | EGFRSRCAURKAKDREPHB4 | |
| SCHEMBL3738451 | 0.84 | KDR (0.62) | EGFRSRCAURKAKDREPHB4 | |
| SCHEMBL3674395 | 0.83 | KDR (0.49) | EGFRSRCAURKAKDREPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092578-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |