Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.76 |
| ▸ | KDR | P35968 | 14/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.61 |
| ▸ | EPHA2 | P29317 | 13/20 | 0.60 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | KIF5B | P33176 | 1/20 | 0.59 |
| ▸ | FLT1 | P17948 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7580350 | 1.00 | SRC (0.76) | SRCKDRERBB2EPHA2EPHB4 | |
| SCHEMBL7580342 | 1.00 | SRC (0.76) | SRCKDRERBB2EPHA2EPHB4 | |
| SCHEMBL7572715 | 0.89 | KDR (0.59) | SRCKDRERBB2EPHA2EPHB4 | |
| SCHEMBL7572708 | 0.89 | KDR (0.59) | SRCKDRERBB2EPHA2EPHB4 | |
| SCHEMBL3206677 | 0.84 | KDR (0.79) | SRCKDRERBB2EPHA2EPHB4 | |
| Azm-475271 SCHEMBL29388701 | 0.84 | KDR (1.00) | SRCKDRERBB2EPHA2EPHB4 | |
| Azm-475271 SCHEMBL3195079 | 0.84 | KDR (1.00) | SRCKDRERBB2EPHA2EPHB4 | |
| Hydrochloric Acid SCHEMBL7591152 | 0.84 | KDR (0.78) | SRCKDRERBB2EPHA2EPHB4 | |
| SCHEMBL5215259 | 0.83 | KDR (0.75) | SRCKDRERBB2EPHA2EPHB4 | |
| SCHEMBL5215250 | 0.83 | KDR (0.75) | SRCKDRERBB2EPHA2EPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092577-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |