Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17162628 | 0.89 | KMT2A (0.52) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL7573905 | 0.83 | MAPT (0.59) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL14378535 | 0.82 | SLC18A3 (0.42) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL4500454 | 0.82 | KDM4E (0.42) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL4560035 | 0.82 | KDM4E (0.42) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL13712017 | 0.82 | KMT2A (0.40) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL4558887 | 0.82 | KMT2A (0.40) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL7571912 | 0.78 | — | — | |
| SCHEMBL4382056 | 0.78 | MEN1 (0.68) | KMT2AMEN1ATMMAPTUSP2 | |
| SCHEMBL10476 | 0.78 | MEN1 (0.68) | KMT2AMEN1ATMMAPTUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002092577-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |
| WO-2002092578-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2002-11-21 | — | — | WO | disclosed |