SCHEMBL7574586

SCHEMBL7574586

CC(N)c1cccc(C(F)(F)F)c1.NCCc1ccc(C(F)(F)F)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 2/20 0.58
MAOB P27338 4/20 0.56
HTR2A P28223 2/20 0.50
HTR2B P41595 2/20 0.50
HTR2C P28335 1/20 0.50
PNMT P11086 1/20 0.49
IDO1 P14902 1/20 0.40
TDO2 P48775 1/20 0.40
SIGMAR1 Q99720 2/20 0.40
TP53 P04637 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
TSHR P16473 1/20 0.40
CYP2C19 P33261 1/20 0.40
TACR1 P25103 1/20 0.39
HRH1 P35367 1/20 0.39
HRH4 Q9H3N8 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504910 0.83 HTR2A (0.58) TAAR1HTR2AHTR2BHTR2CPNMT
SCHEMBL334964 0.83 HTR2A (0.58) TAAR1HTR2AHTR2BHTR2CPNMT
SCHEMBL40102 0.83 HTR2A (0.58) TAAR1HTR2AHTR2BHTR2CPNMT
SCHEMBL1728826 0.83 HTR2A (0.58) TAAR1HTR2AHTR2BHTR2CPNMT
Hydrochloric Acid SCHEMBL23246369 0.82 HTR2A (0.56) HTR2AHTR2BHTR2CPNMTIDO1
Methane SCHEMBL8899008 0.82 HTR2A (0.56) HTR2AHTR2BHTR2CPNMTIDO1
Hydrochloric Acid SCHEMBL14121095 0.82 HTR2A (0.56) HTR2AHTR2BHTR2CPNMTIDO1
Hydrochloric Acid SCHEMBL7787892 0.82 HTR2A (0.56) HTR2AHTR2BHTR2CPNMTIDO1
SCHEMBL10913587 0.79 IDO1 (0.57) HTR2AHTR2BHTR2CPNMTIDO1
SCHEMBL7784429 0.78 TAAR1 (0.66) TAAR1MAOBHTR2AHTR2BHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1144399-A3 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP Wyeth (US) 2002-09-11 EP disclosed
EP-1144399-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-17 EP disclosed
EP-1137647-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2001-10-04 EP disclosed
WO-2000034261-A2 HETEROCYCLIC CARBOXAMIDE-CONTAINING THIOUREA INHIBITORS OF HERPES VIRUSES CONTAINING A SUBSTITUTED PHENYLENEDIAMINE GROUP AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed
WO-2000034268-A1 THIOUREA INHIBITORS OF HERPES VIRUSES AMERICAN HOME PRODUCTS CORPORATION (US) 2000-06-15 WO disclosed