Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 19/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757568 | 1.00 | GRM2 (1.00) | GRM2ALOX5KCNH2GRM3 | |
| SCHEMBL757557 | 0.93 | GRM2 (0.88) | GRM2GRM3 | |
| SCHEMBL757558 | 0.93 | GRM2 (0.88) | GRM2GRM3 | |
| SCHEMBL758745 | 0.92 | GRM2 (0.85) | GRM2ALOX5KCNH2GRM3 | |
| SCHEMBL757250 | 0.92 | GRM2 (1.00) | GRM2ALOX5KCNH2GRM3 | |
| SCHEMBL756591 | 0.92 | GRM2 (1.00) | GRM2ALOX5KCNH2GRM3 | |
| SCHEMBL756328 | 0.92 | GRM2 (0.84) | GRM2ALOX5KCNH2GRM3 | |
| SCHEMBL758216 | 0.92 | GRM2 (0.84) | GRM2ALOX5KCNH2GRM3 | |
| SCHEMBL758394 | 0.91 | GRM2 (1.00) | GRM2GRM3 | |
| SCHEMBL757045 | 0.91 | GRM2 (1.00) | GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118093-B1 | [1,2,3]TRIAZOLYL SUBSTITUTED QUINOLINES AND COUMARINS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK CANADA INC (CA) | 2012-03-21 | — | — | EP | disclosed |