Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 16/20 | 0.78 |
| ▸ | PIK3CA | P42336 | 15/20 | 0.78 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL755585 | 0.90 | MTOR (0.81) | MTORPIK3CAKDM4EALDH1A1LMNA | |
| SCHEMBL757042 | 0.88 | MTOR (0.78) | MTORPIK3CAKDM4EALDH1A1LMNA | |
| SCHEMBL2787359 | 0.88 | MTOR (1.00) | MTORPIK3CAADORA2AADORA1 | |
| SCHEMBL11031102 | 0.88 | MTOR (0.77) | MTORPIK3CAKDM4EALDH1A1LMNA | |
| SCHEMBL2789558 | 0.88 | MTOR (0.77) | MTORPIK3CAMKNK1ABL1 | |
| SCHEMBL752869 | 0.84 | MTOR (0.70) | MTORPIK3CA | |
| SCHEMBL755586 | 0.83 | MTOR (0.75) | MTORPIK3CA | |
| SCHEMBL2786633 | 0.82 | MTOR (0.76) | MTORPIK3CAADORA2AADORA1 | |
| SCHEMBL2774086 | 0.81 | MTOR (0.69) | MTORPIK3CA | |
| SCHEMBL755072 | 0.81 | MTOR (0.73) | MTORPIK3CAABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2430013-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | Amgen, Inc (US) | 2012-03-21 | — | — | EP | claimed |
| WO-2010132598-A1 | HETEROARYL COMPOUNDS AS PIKK INHIBITORS | AMGEN INC. (US) | 2010-11-18 | — | — | WO | claimed |