SCHEMBL7577322

SCHEMBL7577322

Oc1ccccc1-c1nc(-c2ccccc2)nc(-c2ccccc2O)n1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.82
ADORA2A P29274 2/20 0.82
ADORA3 P0DMS8 1/20 0.82
ALOX15 P16050 1/20 0.82
ADORA2B P29275 1/20 0.82
ADORA1 P30542 1/20 0.82
ALDH1A1 P00352 2/20 0.60
HSD17B10 Q99714 2/20 0.60
HPGD P15428 1/20 0.60
BCL2L1 Q07817 1/20 0.60
CASP3 P42574 3/20 0.59
SENP8 Q96LD8 3/20 0.59
SENP7 Q9BQF6 3/20 0.59
SENP6 Q9GZR1 3/20 0.59
CHUK O15111 1/20 0.59
TXNRD1 Q16881 1/20 0.59
NOX4 Q9NPH5 1/20 0.59
SMN1; SMN2 Q16637 4/20 0.59
MAPK1 P28482 2/20 0.58
LMNA P02545 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL296255 1.00 TSHR (0.82) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL29481861 1.00 TSHR (0.82) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL15908068 0.98 TSHR (0.79) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL15908054 0.98 ADORA2A (0.79) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL4029619 0.96 ADORA2A (0.77) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL1830032 0.96 ADORA2A (0.77) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL15908091 0.96 ADORA2A (0.77) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL6334711 0.96 ADORA2A (0.77) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL15908069 0.94 TSHR (0.74) TSHRADORA2AADORA3ALOX15ADORA2B
SCHEMBL15908109 0.92 ADORA2A (0.72) TSHRADORA2AADORA3ALOX15ADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0658156-B1 HYDROXYPHENYL-S-TRIAZINES CIBA SC HOLDING AG (CH) 2002-10-09 EP disclosed
US-5942564-A OXIDATION AND HEAT RESISTANCE; PHOTOSTABILITY CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-08-24 US disclosed
EP-0658156-A1 HYDROXYPHENYL-S-TRIAZINES Ciba SC Holding AG (CH) 1995-06-21 EP disclosed
EP-0205493-B1 USE OF SULFONATED 2-(2'-HYDROXYARYL)-s-TRIAZINES AS PHOTOSTABILISING AGENTS FOR WOOL AND OTHER PROTEIN FIBRES COMMW SCIENT IND RES ORG (AU) 1994-09-07 EP disclosed
WO-1994005645-A1 HYDROXYPHENYL-S-TRIAZINES CIBA-GEIGY AG (CH) 1994-03-17 WO disclosed
EP-0205493-A4 USE OF SULFONATED 2-(2'-HYDROXYARYL)-s-TRIAZINES AS PHOTOSTABILISING AGENTS FOR WOOL AND OTHER PROTEIN FIBRES. COMMW SCIENT IND RES ORG (AU) 1988-09-19 EP disclosed
US-4698064-A Use of sulfonated 2-(2'-hydroxyaryl)-s-triazines as photostabilizing agents for wool and other protein fibres COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORG. (AU) 1987-10-06 US disclosed
EP-0205493-A1 USE OF SULFONATED 2-(2'-HYDROXYARYL)-s-TRIAZINES AS PHOTOSTABILISING AGENTS FOR WOOL AND OTHER PROTEIN FIBRES. COMMW SCIENT IND RES ORG (AU) 1986-12-30 EP disclosed
WO-1986003528-A1 USE OF SULFONATED 2-(2'-HYDROXYARYL)-s-TRIAZINES AS PHOTOSTABILISING AGENTS FOR WOOL AND OTHER PROTEIN FIBRES COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR (AU) 1986-06-19 WO disclosed