Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Valproic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.94 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.94 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.94 |
| ▸ | HTR2A | P28223 | 1/20 | 0.94 |
| ▸ | HTR2C | P28335 | 1/20 | 0.94 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.94 |
| ▸ | HRH1 | P35367 | 1/20 | 0.94 |
| ▸ | DRD3 | P35462 | 1/20 | 0.94 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.94 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.94 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.94 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.94 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.60 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 4/20 | 0.60 |
| ▸ | SLC1A3 | P43003 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Valproic Acid SCHEMBL2054191 | 1.00 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL244738 | 1.00 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL6910916 | 1.00 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL1685069 | 1.00 | CHRM1 (0.94) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL27925984 | 0.97 | CHRM1 (0.89) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL28857465 | 0.97 | CHRM1 (0.89) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL2275 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL1330837 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL140241 | 0.97 | CHRM1 (1.00) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Valproic Acid SCHEMBL28895465 | 0.95 | CHRM1 (0.84) | CHRM1AKR1A1CHRM3HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808161-B1 | SOLID SUBSTANCES COMPRISING VALPROIC ACID AND SODIUM VALPROATE | SHERMAN BERNARD CHARLES (CA) | 2002-09-11 | — | — | EP | claimed |
| US-6077542-A | HEATING VALPROIC ACID, DISSOLVING SODIUM VALPROATE THEREIN, COOLING BELOW MELTING POINT | SHERMAN BERNARD CHARLES (CA) | 2000-06-20 | — | — | US | claimed |
| EP-0808161-A1 | SOLID SUBSTANCES COMPRISING VALPROIC ACID AND SODIUM VALPROATE | SHERMAN, Bernard Charles (CA) | 1997-11-26 | — | — | EP | claimed |
| WO-1996023491-A1 | SOLID SUBSTANCES COMPRISING VALPROIC ACID AND SODIUM VALPROATE | SHERMAN BERNARD CHARLES (CA) | 1996-08-08 | — | — | WO | claimed |
| CN-118556079-A | Compositions and methods of anti-PACAP antibodies | 瑟法隆有限责任公司 | 2024-08-27 | — | — | CN | disclosed |
| CN-107849010-B | 3, 3-difluoropiperidine carbamate heterocycles as NR2B NMDA receptor antagonists | 卢郡控股(开曼)有限公司 | 2021-11-09 | — | — | CN | disclosed |
| US-6333352-B1 | ANTIEPILEPTIC DRUGS SUCH AS DIVALPROEX SODIUM OR GABAPENTIN FOR TREATMENT OF BENIGN POSITIONAL VERTIGO | MIMICKING MAN MANUALLY, INC. | 2001-12-25 | — | — | US | disclosed |
| WO-2001076590-A2 | TREATMENT FOR BENIGN POSITIONAL VERTIGO USING ANTIEPILEPTICS | MIMICKING MAN MANUALLY, INC. (US) | 2001-10-18 | — | — | WO | disclosed |