Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585008 | 0.91 | CHRNA7 (0.57) | CHRNA7ADORA2AADORA1GAARAD52 | |
| SCHEMBL7586804 | 0.85 | CHRNA7 (0.50) | CHRNA7ADORA2AADORA1GAAHTR7 | |
| SCHEMBL7582941 | 0.84 | CHRNA7 (0.49) | CHRNA7ADORA2AADORA1GAAHTR7 | |
| SCHEMBL7583969 | 0.83 | CHRNA7 (0.48) | CHRNA7ADORA2AADORA1HTR7MAPT | |
| SCHEMBL7583633 | 0.82 | ADORA2A (0.45) | CHRNA7ADORA2AADORA1GAARAD52 | |
| SCHEMBL7584764 | 0.82 | CHRNA7 (0.47) | CHRNA7ADORA2AADORA1HTR7DRD2 | |
| SCHEMBL7585478 | 0.82 | CHRNA7 (0.47) | CHRNA7ADORA2AADORA1GAAHTR7 | |
| SCHEMBL7584437 | 0.82 | CHRNA7 (0.47) | CHRNA7ADORA2AADORA1GAAHTR7 | |
| SCHEMBL7591005 | 0.81 | CHRNA7 (0.46) | CHRNA7ADORA2AADORA1GAARAD52 | |
| SCHEMBL7582348 | 0.81 | CHRNA7 (0.46) | CHRNA7ADORA2AADORA1HTR7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |