Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 20/20 | 0.60 |
| ▸ | PTPRC | P08575 | 19/20 | 0.60 |
| ▸ | PTPN2 | P17706 | 18/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944264 | 0.83 | PTPN1 (0.83) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7526513 | 0.82 | PTPN1 (0.77) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7530510 | 0.81 | PTPN1 (0.75) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7564653 | 0.80 | PTPN1 (0.54) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7524763 | 0.79 | PTPN1 (0.61) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7561036 | 0.79 | PTPN1 (0.58) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7583197 | 0.78 | PTPN1 (0.54) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7526715 | 0.76 | PTPN1 (0.80) | PTPN1PTPRCPTPN2 | |
| SCHEMBL6944093 | 0.76 | PTPN1 (0.84) | PTPN1PTPRCPTPN2 | |
| SCHEMBL7558349 | 0.75 | PTPN1 (0.53) | PTPN1PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486141-B2 | TREATING OR PREVENTING PTP-1B MEDIATED DISEASES, INCLUDING DIABETES, OBESITY, AND DIABETES-RELATED CONDITIONS. | MERCK FROSST CANADA & CO. (CA) | 2002-11-26 | — | — | US | disclosed |
| US-20020052346-A1 | Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | MERCK FROSST CANADA LTD. (CA) | 2002-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020052346-A1 | Phosphonic acid biaryl derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B) | PTPRO, PPM1B, PTPA | PTPN1 15/4885PTPRC 4/4885PTPN2 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.