Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | Q9HBH1 | 3/20 | 0.47 | |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9360054 | 0.84 | KMT2A (0.59) | KMT2AHPGDRAB9AMAPTNPC1 | |
| SCHEMBL6357074 | 0.83 | KMT2A (0.68) | KMT2AHPGDRAB9AMAPTNPC1 | |
| SCHEMBL28358891 | 0.83 | AKR1C3 (0.56) | KMT2ARAB9AMAPTNPC1HTT | |
| SCHEMBL7585613 | 0.83 | NR4A1 (0.56) | KMT2AHPGDRAB9AMAPTNPC1 | |
| SCHEMBL30822629 | 0.83 | KMT2A (0.63) | KMT2AHPGDRAB9AMAPTNPC1 | |
| SCHEMBL257374 | 0.82 | AKR1C3 (0.52) | KMT2AHPGDMAPTPOLBNPSR1 | |
| SCHEMBL1407369 | 0.81 | KMT2A (0.56) | KMT2AHPGDRAB9AMAPTNPC1 | |
| SCHEMBL11842416 | 0.80 | KMT2A (0.55) | KMT2AHPGDRAB9AMAPTNPC1 | |
| SCHEMBL9712552 | 0.80 | KMT2A (0.55) | KMT2AHPGDRAB9AMAPTNPC1 | |
| SCHEMBL15760640 | 0.80 | KMT2A (0.56) | KMT2AHPGDRAB9AMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | disclosed |
| US-5886178-A | ADMINISTERING OF A PROSTAGLANDIN G/H SYNTHASE INHIBITOR TO A PATIENT TO TREAT INFLAMMATORY OR AUTOIMMUNE DISEASES | SYNTEX (U.S.A.) INC. (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |