Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | RARG | P13631 | 14/20 | 0.36 |
| ▸ | RARB | P10826 | 5/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 4/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | CDC25A | P30304 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472627 | 0.81 | CYP26A1 (0.42) | RARGRARBRXRARARA | |
| SCHEMBL6472625 | 0.81 | CYP26A1 (0.42) | RARGRARBRXRARARA | |
| SCHEMBL18969683 | 0.76 | EGFR (0.44) | EGFRTP53ADRB2PTPN1 | |
| SCHEMBL6473205 | 0.75 | TP53 (0.42) | TP53CYP1A2RARGRARBRARA | |
| SCHEMBL5847404 | 0.73 | RARG (0.69) | RARGRARBRXRARARA | |
| SCHEMBL6473259 | 0.72 | TP53 (0.40) | TP53CYP1A2RARGRARBRXRA | |
| SCHEMBL26943123 | 0.72 | RARB (0.41) | TP53CYP1A2RARGRARBRXRA | |
| SCHEMBL5846718 | 0.72 | RARG (0.43) | RARGRARBRXRARARA | |
| SCHEMBL23421819 | 0.71 | RARB (0.45) | TP53CYP1A2RARGRARBRXRA | |
| SCHEMBL5846349 | 0.70 | RARG (0.44) | RARGRARBRXRARARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0947496-B1 | Bicyclic aromatic compounds and their use in human and veterinary medicine as well as in cosmetology | GALDERMA RES & DEV (FR) | 2002-10-09 | — | — | EP | disclosed |
| EP-0947496-A1 | Bicyclic aromatic compounds and their use in human and veterinary medicine as well as in cosmetology | Galderma Research & Development, S.N.C. (FR) | 1999-10-06 | — | — | EP | disclosed |