Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | CSF1R | P07333 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | LTK | P29376 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.64 |
| ▸ | PRKX | P51817 | 1/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.64 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.64 |
| ▸ | MST1R | Q04912 | 1/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.64 |
| ▸ | BTK | Q06187 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL261827 | 0.98 | PLK4 (0.62) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| Formic Acid SCHEMBL27926844 | 0.94 | PLK4 (0.57) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL27926842 | 0.84 | PLK4 (0.60) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL14738150 | 0.83 | PLK4 (0.59) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL28146647 | 0.83 | PLK4 (0.59) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL20616534 | 0.81 | PLK4 (0.70) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL24433138 | 0.81 | PLK4 (0.64) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL11578958 | 0.80 | PLK4 (0.59) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL29520722 | 0.80 | PLK4 (0.72) | PLK4CHEK1AURKADAPK3MAP4K4 | |
| SCHEMBL259689 | 0.80 | PLK4 (0.72) | PLK4CHEK1AURKADAPK3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107835814-A | Azabenzimidazoles and their use as ampa receptor modulators | 詹森药业有限公司 | 2018-03-23 | — | — | CN | claimed |
| US-20250353829-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | TEMPEST THERAPEUTICS INC (US) | 2025-11-20 | — | — | US | disclosed |
| EP-4232431-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH LPA RECEPTOR ACTIVITY | LHOTSE BIO INC (US) | 2025-08-13 | — | — | EP | disclosed |
| CN-119487006-A | Amide compounds as PGE2 receptor antagonists | 广东新契生物医药科技有限公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-117800916-B | Preparation and application of 1- [ (1H-indazol-7-yl) methyl ] -3-arylthiourea derivative | 沈阳药科大学 | 2025-02-11 | — | — | CN | disclosed |
| US-12215093-B2 | Bicyclic carboxamides and methods of use thereof | TEMPEST THERAPEUTICS, INC. (US) | 2025-02-04 | — | — | US | disclosed |
| EP-3781550-B1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | TEMPEST THERAPEUTICS INC (US) | 2024-10-30 | — | — | EP | disclosed |
| US-20240150316-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | TEMPEST THERAPEUTICS, INC. | 2024-05-09 | — | — | US | disclosed |
| CN-112313208-B | Bicyclic carboxamides and methods of use thereof | 泰普斯特医疗公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-101426779-A | Pesticide containing bicyclic bisamide structure | SYNGENTA PARTICIPATIONS AG (CH) | 2009-05-06 | — | — | CN | disclosed |
| EP-2013169-A1 | INDOLE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | Merck Frosst Canada Ltd. (CA) | 2009-01-14 | — | — | EP | disclosed |
| EP-2007733-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2008-12-31 | — | — | EP | disclosed |
| EP-1984354-A1 | PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE | Syngeta Participations AG (CH) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007121578-A1 | INDOLE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007121578-A1 | INDOLE AMIDE DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | MERCK FROSST CANADA LTD. (CA) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007113596-A1 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-10-11 | — | — | WO | disclosed |
| WO-2007093402-A1 | PESTICIDES CONTAINING A BICYCLIC BISAMIDE STRUCTURE | SYNGENTA PARTICIPATIONS AG (CH) | 2007-08-23 | — | — | WO | disclosed |
| EP-1628972-A1 | INDAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS | Sanofi-Aventis Deutschland GmbH (DE) | 2006-03-01 | — | — | EP | disclosed |
| WO-2004101556-A1 | INDAZOLE-DERIVATIVES AS FACTOR Xa INHIBITORS | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2004-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240150316-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | PTGER4, PTGER2, CNR2 | PLK4 2831/4885CHEK1 4044/4885AURKA 4109/4885 |
| US-20250353829-A1 | BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF | PTGER4, PTGER2, CNR2 | PLK4 2831/4885CHEK1 4044/4885AURKA 4109/4885 |
| US-12215093-B2 | Bicyclic carboxamides and methods of use thereof | PTGER4, PTGER2, CNR2 | PLK4 2831/4885CHEK1 4044/4885AURKA 4109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.