Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 5/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7583536 | 0.91 | CHRNA7 (0.43) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7585552 | 0.89 | CHRNA7 (0.41) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7581507 | 0.87 | CHRNA7 (0.39) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7583814 | 0.87 | CHRNA7 (0.45) | CHRNA7HTR7ADORA2AADORA1POLB | |
| SCHEMBL7583442 | 0.86 | ADORA2A (0.38) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7585008 | 0.86 | CHRNA7 (0.57) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7585918 | 0.85 | ADORA2A (0.38) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7584430 | 0.84 | CHRNA7 (0.47) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7586804 | 0.82 | CHRNA7 (0.50) | CHRNA7HTR7ADORA2AADORA1DRD2 | |
| SCHEMBL7582941 | 0.81 | CHRNA7 (0.49) | CHRNA7HTR7ADORA2AADORA1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | claimed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | claimed |
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |