Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5248372 | 0.79 | PRCP (0.70) | PRCPDRD2TRPM8DRD1SLC6A4 | |
| SCHEMBL7585517 | 0.76 | PRCP (0.65) | PRCPDRD2TRPM8DRD1SLC6A4 | |
| SCHEMBL25604565 | 0.76 | PRCP (1.00) | PRCPDRD2DRD1 | |
| SCHEMBL8415128 | 0.76 | PRCP (1.00) | PRCPDRD2DRD1 | |
| SCHEMBL13928812 | 0.76 | PRCP (1.00) | PRCPDRD2DRD1 | |
| SCHEMBL12312005 | 0.75 | PRCP (0.56) | PRCPDRD2HTR1AHTR7DRD1 | |
| Iodide SCHEMBL27518895 | 0.74 | PRCP (0.97) | PRCPDRD2DRD1 | |
| SCHEMBL8021507 | 0.73 | PRCP (0.61) | PRCPDRD2HTR1ADRD1DRD4 | |
| SCHEMBL8023492 | 0.73 | PRCP (0.61) | PRCPDRD2HTR1ADRD1DRD4 | |
| SCHEMBL811761 | 0.73 | PRCP (0.61) | PRCPDRD2HTR1ADRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246805-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2002-10-09 | — | — | EP | claimed |
| WO-2001032624-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-05-10 | — | — | WO | claimed |