Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29675989 | 0.86 | CYP3A4 (0.50) | GAAMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL21050901 | 0.86 | CYP3A4 (0.50) | GAAMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL26694609 | 0.82 | GAA (0.46) | GAAMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL21050751 | 0.82 | GAA (0.46) | GAAMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL12397904 | 0.77 | GAA (0.42) | GAAMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL5660899 | 0.77 | POLB (0.47) | GAAMAPTALDH1A1TSHRMAPK1 | |
| SCHEMBL525650 | 0.75 | CYP3A4 (0.65) | GAAMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL25259748 | 0.73 | TDP1 (0.47) | CYP3A4ALDH1A1TSHRCA1CA2 | |
| SCHEMBL9323230 | 0.73 | MAPT (0.65) | GAAMAPTCYP3A4TP53ALDH1A1 | |
| SCHEMBL5076239 | 0.73 | MAPT (1.00) | GAAMAPTCYP3A4TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| CN-1117966-A | Biphenyl derivatives | EISAI CO LTD (JP) | 1996-03-06 | — | — | CN | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |