Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 13/20 | 1.00 |
| ▸ | JAK2 | O60674 | 2/20 | 0.67 |
| ▸ | JAK3 | P52333 | 2/20 | 0.67 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015903 | 1.00 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7017830 | 0.92 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7016498 | 0.91 | LCK (0.83) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7593834 | 0.89 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7019333 | 0.89 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7016983 | 0.89 | LCK (0.87) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7023052 | 0.88 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7015965 | 0.88 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7017465 | 0.88 | LCK (0.89) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7014962 | 0.87 | LCK (0.80) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |