Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.74 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7015973 | 1.00 | LCK (0.74) | LCKJAK2JAK3FGFR1IDH1 | |
| SCHEMBL7017482 | 0.92 | LCK (0.74) | LCKJAK2JAK3IDH1AURKA | |
| SCHEMBL7017800 | 0.89 | LCK (0.70) | LCKJAK2JAK3IDH1AURKA | |
| SCHEMBL7015965 | 0.85 | LCK (1.00) | LCKJAK2JAK3FGFR1IDH1 | |
| SCHEMBL7015912 | 0.84 | LCK (0.69) | LCKJAK2JAK3FGFR1AURKA | |
| SCHEMBL7014492 | 0.81 | LCK (0.67) | LCKJAK2JAK3FGFR1MKNK1 | |
| SCHEMBL7015030 | 0.79 | LCK (0.71) | LCKJAK2JAK3IDH1AURKA | |
| SCHEMBL7021040 | 0.78 | LCK (0.64) | LCKJAK2JAK3AURKAAURKB | |
| SCHEMBL7505890 | 0.78 | MKNK2 (0.57) | LCKFGFR1MKNK1MKNK2 | |
| SCHEMBL3149082 | 0.78 | LCK (0.66) | LCKJAK2JAK3FGFR1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |