SCHEMBL7589274

SCHEMBL7589274

CCOC(=O)c1cc(Cl)cc(C(=O)OCC)c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.62
CA1 P00915 3/20 0.62
CA2 P00918 3/20 0.62
CA7 P43166 3/20 0.62
CA9 Q16790 3/20 0.62
CA14 Q9ULX7 3/20 0.62
CYP2C19 P33261 2/20 0.53
CYP2C9 P11712 1/20 0.53
ESR1 P03372 2/20 0.52
ESR2 Q92731 1/20 0.52
CYP1A2 P05177 2/20 0.50
LMNA P02545 1/20 0.50
CYP3A4 P08684 1/20 0.50
MAOA P21397 1/20 0.50
KMT2A Q03164 2/20 0.49
MEN1 O00255 1/20 0.49
TRPV1 Q8NER1 1/20 0.48
KDM4E B2RXH2 1/20 0.47
CYP2D6 P10635 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2662880 0.96 CA12 (0.62) CA12CA1CA2CA7CA9
SCHEMBL2707377 0.93 CYP2C9 (0.60) CA12CA1CA2CA7CA9
SCHEMBL15615318 0.90 CA12 (0.56) CA12CA1CA2CA7CA9
SCHEMBL1664013 0.89 CA12 (0.75) CA12CA1CA2CA7CA9
SCHEMBL4758271 0.89 CA12 (0.55) CA12CA1CA2CA7CA9
SCHEMBL583546 0.87 NPC1 (0.59) CA12CA1CA2CA7CA9
SCHEMBL29944874 0.84 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL16528649 0.84 CYP4F2 (0.54) CA12CA1CA2CA7CA9
SCHEMBL27030501 0.84 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL265366 0.83 CA12 (0.67) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0855400-B1 Phenylphosphonic acid derivative and production process therefor NISSAN CHEMICAL IND LTD (JP) 2002-11-06 EP disclosed
US-5880309-A DIALKYL DIALKOXYCARBONYLPHENYL PHOSPHONATES USEFUL AS RESIN MODIFIERS PRODUCED AT HIGH YIELD AND LOW COST BY HEATING A TRIALKYL PHOSPHITE AND A DIALKOXYCARBONYLPHENYL HALIDE IN THE PRESENCE OF A PALLADIUM OR NICKEL CATALYST AND HYDROLYZING NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1999-03-09 US disclosed
EP-0855400-A1 Phenylphosphonic acid derivative and production process therefor NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1998-07-29 EP disclosed