Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.69 |
| ▸ | MET | P08581 | 7/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.69 |
| ▸ | SRC | P12931 | 6/20 | 0.69 |
| ▸ | EGFR | P00533 | 3/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.69 |
| ▸ | LCK | P06239 | 2/20 | 0.69 |
| ▸ | YES1 | P07947 | 2/20 | 0.69 |
| ▸ | KIT | P10721 | 2/20 | 0.69 |
| ▸ | NEK2 | P51955 | 2/20 | 0.69 |
| ▸ | PLK4 | O00444 | 1/20 | 0.69 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.69 |
| ▸ | CASK | O14936 | 1/20 | 0.69 |
| ▸ | GAK | O14976 | 1/20 | 0.69 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147155 | 1.00 | KDR (0.69) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL146781 | 0.91 | SRC (0.59) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL142964 | 0.90 | KDR (0.69) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL144929 | 0.88 | KDR (0.70) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL147361 | 0.87 | KDR (0.72) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL142239 | 0.87 | KDR (0.80) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL7122491 | 0.86 | KDR (0.79) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL141560 | 0.86 | KDR (0.70) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL144212 | 0.86 | KDR (0.70) | KDRFGFR1METPDGFRBSRC | |
| SCHEMBL143746 | 0.86 | KDR (0.67) | KDRFGFR1METPDGFRBSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |