Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595710 | 0.86 | POLB (0.53) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL7589856 | 0.85 | POLB (0.52) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL7595713 | 0.85 | POLB (0.52) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL6094935 | 0.84 | POLB (0.53) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL6257594 | 0.80 | POLB (0.52) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL29660878 | 0.78 | POLB (0.70) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL4662993 | 0.78 | POLB (0.70) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL6092274 | 0.73 | POLB (0.53) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL12793683 | 0.73 | POLB (0.72) | POLBALDH1A1HPGDMAPK1HTR2C | |
| SCHEMBL5960083 | 0.73 | KMT2A (0.72) | POLBALDH1A1HPGDMAPK1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001087842-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL PYRIDONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE | PHARMACIA CORPORATION (US) | 2001-11-22 | — | — | WO | disclosed |