Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.64 |
| ▸ | FLT3 | P36888 | 2/20 | 0.64 |
| ▸ | LCK | P06239 | 12/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7016843 | 1.00 | KIT (0.64) | KITFLT3LCKMEN1GAA | |
| SCHEMBL7593220 | 0.90 | LCK (0.63) | KITFLT3LCKMEN1GAA | |
| SCHEMBL7020378 | 0.90 | LCK (0.63) | KITFLT3LCKMEN1GAA | |
| SCHEMBL7017436 | 0.89 | LCK (0.71) | LCKMEN1KMT2AJAK2JAK3 | |
| SCHEMBL7594389 | 0.89 | LCK (0.71) | LCKMEN1KMT2AJAK2JAK3 | |
| SCHEMBL7021145 | 0.89 | LCK (0.61) | KITFLT3LCKGAAJAK2 | |
| SCHEMBL7019330 | 0.89 | LCK (0.63) | KITFLT3LCKMEN1GAA | |
| SCHEMBL7024664 | 0.89 | LCK (0.63) | KITFLT3LCKMEN1GAA | |
| SCHEMBL7022207 | 0.89 | LCK (0.63) | KITFLT3LCKMEN1GAA | |
| SCHEMBL7020148 | 0.87 | LCK (0.59) | KITFLT3LCKMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |