Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 11/20 | 0.75 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | IDH1 | O75874 | 5/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7019614 | 1.00 | LCK (0.75) | LCKJAK2JAK3IDH1MKNK1 | |
| SCHEMBL7019499 | 0.93 | LCK (0.81) | LCKJAK2JAK3IDH1MKNK1 | |
| SCHEMBL7014066 | 0.91 | LCK (0.76) | LCKJAK2JAK3IDH1MKNK1 | |
| SCHEMBL7020879 | 0.91 | LCK (0.90) | LCKJAK2JAK3IDH1MKNK1 | |
| SCHEMBL7016498 | 0.88 | LCK (0.83) | LCKJAK2JAK3IDH1MKNK1 | |
| SCHEMBL7589537 | 0.88 | LCK (0.81) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7019110 | 0.88 | LCK (0.81) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7018899 | 0.87 | LCK (0.78) | LCKJAK2JAK3IDH1MKNK1 | |
| SCHEMBL7590025 | 0.86 | LCK (0.74) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7024206 | 0.86 | LCK (0.74) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |