Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 15/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | PLEC | Q15149 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7597198 | 0.92 | NPSR1 (0.37) | GNRHRKMT2AKCNH2MEN1 | |
| SCHEMBL7594784 | 0.91 | GNRHR (0.35) | GNRHRKMT2AEDNRBKCNH2MEN1 | |
| SCHEMBL6704311 | 0.91 | GNRHR (0.36) | GNRHRKMT2AEDNRBKCNH2 | |
| SCHEMBL7595053 | 0.91 | GNRHR (0.35) | GNRHRKMT2AEDNRBKCNH2MEN1 | |
| SCHEMBL7591544 | 0.91 | GNRHR (0.43) | GNRHRKMT2AEDNRB | |
| SCHEMBL7590037 | 0.90 | GNRHR (0.34) | GNRHRKMT2AEDNRBKCNH2 | |
| SCHEMBL8189365 | 0.87 | GNRHR (0.34) | GNRHRKMT2AEDNRB | |
| SCHEMBL7592033 | 0.86 | GNRHR (0.37) | GNRHRKMT2AEDNRBKCNH2 | |
| SCHEMBL7592371 | 0.86 | GNRHR (0.35) | GNRHRKMT2AEDNRB | |
| SCHEMBL7597312 | 0.86 | MEN1 (0.36) | GNRHRKMT2AEDNRBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |