Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 12/20 | 0.47 |
| ▸ | CCKAR | P32238 | 9/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.45 |
| ▸ | CBLB | Q13191 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7092438 | 0.80 | KCNH2 (0.48) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL4416902 | 0.77 | PSEN1 (0.53) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL8681102 | 0.77 | PSEN1 (0.53) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL8681100 | 0.77 | PSEN1 (0.53) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL8824704 | 0.77 | PSEN1 (0.53) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL8824697 | 0.77 | PSEN1 (0.53) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL8824701 | 0.77 | PSEN1 (0.53) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL9301646 | 0.76 | PSEN1 (0.52) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL9301649 | 0.76 | PSEN1 (0.52) | CCKBRCCKARPSEN1PSEN2APH1B | |
| SCHEMBL9301651 | 0.76 | PSEN1 (0.52) | CCKBRCCKARPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002099388-A2 | BENZODIAZEPINE BRADYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 2002-12-12 | — | — | WO | claimed |
| WO-2002099388-A2 | BENZODIAZEPINE BRADYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 2002-12-12 | — | — | WO | disclosed |