Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.66 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.66 |
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.57 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9460524 | 0.92 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL22209138 | 0.87 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL29587861 | 0.87 | CYSLTR1 (0.59) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL8651397 | 0.84 | CYSLTR1 (0.63) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL7593162 | 0.84 | GPBAR1 (0.67) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL7599035 | 0.84 | CYSLTR1 (0.62) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL7599091 | 0.83 | GPBAR1 (0.65) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL7599114 | 0.83 | GPBAR1 (0.65) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL7599101 | 0.82 | GPBAR1 (0.60) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A | |
| SCHEMBL7592902 | 0.82 | GPBAR1 (0.64) | CYSLTR1CYSLTR2GPBAR1ALOX5PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | claimed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | claimed |
| EP-0862557-B1 | SYMMETRICAL bis-HETEROARYLMETHOXYPHENYLALKYL CARBOXYLATES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LAB (US) | 2002-11-27 | — | — | EP | disclosed |
| US-5843968-A | Symmetrical bis-heteroarylmethoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-12-01 | — | — | US | disclosed |
| US-5795900-A | Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-08-18 | — | — | US | disclosed |
| US-5783586-A | Heteroarylmethoxyphenylthioalkyl carboxylates as inhibitors of leukotriene biosynthesis | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |