SCHEMBL7595789

SCHEMBL7595789

CCOC(=O)c1nc2c(NC(C)CO)nc(SCc3cccc(F)c3F)nc2[nH]c1=O

nearest known ligand 0.86

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CXCR2 P25025 20/20 0.86
CCR7 P32248 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3857594 1.00 CXCR2 (0.86) CXCR2CCR7
SCHEMBL3850177 0.87 CXCR2 (0.77) CXCR2CCR7
SCHEMBL5189218 0.84 CXCR2 (0.79) CXCR2CCR7
SCHEMBL5190675 0.84 CXCR2 (0.76) CXCR2CCR7
SCHEMBL3856241 0.84 CXCR2 (0.61) CXCR2CCR7
SCHEMBL5190682 0.84 CXCR2 (0.76) CXCR2CCR7
SCHEMBL3857600 0.84 CXCR2 (0.61) CXCR2CCR7
SCHEMBL3856461 0.83 CXCR2 (0.73) CXCR2CCR7
SCHEMBL5189502 0.82 CXCR2 (0.73) CXCR2CCR7
SCHEMBL5189173 0.82 CXCR2 (0.72) CXCR2CCR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1259512-A1 PTERIDINE COMPOUNDS FOR THE TREATMENT OF PSORIASIS AstraZeneca AB (SE) 2002-11-27 EP disclosed
WO-2001062758-A1 PTERIDINE COMPOUNDS FOR THE TREATMENT OF PSORIASIS ASTRAZENECA AB (SE) 2001-08-30 WO disclosed