SCHEMBL7596258

SCHEMBL7596258

CSc1nc(N)nc2c1ncn2CCOCP(CC(F)(F)F)CC(F)(F)F

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 4/20 0.41
CYP1A2 P05177 6/20 0.39
CYP3A4 P08684 3/20 0.39
CYP2C9 P11712 3/20 0.39
HIF1A Q16665 3/20 0.39
CYP2D6 P10635 2/20 0.39
SLC29A1 Q99808 3/20 0.39
CDK1 P06493 3/20 0.38
CCNB1 P14635 3/20 0.38
CCNE1 P24864 3/20 0.38
CDK2 P24941 3/20 0.38
TDP1 Q9NUW8 1/20 0.38
HK1 P19367 1/20 0.38
HKDC1 Q2TB90 1/20 0.38
ALDH1A1 P00352 1/20 0.36
PHLPP2 Q6ZVD8 1/20 0.36
TSHR P16473 1/20 0.35
POLB P06746 2/20 0.35
TLR9 Q9NR96 2/20 0.34
TLR7 Q9NYK1 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7900014 0.90 CYP2C19 (0.47) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL7593063 0.88 SLC29A1 (0.54) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL7596474 0.86 SLC29A1 (0.48) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL7753509 0.86 CDK1 (0.51) CDK1CCNB1CCNE1CDK2POLB
SCHEMBL7759477 0.86 CYP2C19 (0.38) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL7769163 0.85 CYP1A2 (0.37) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL7128679 0.85 CYP1A2 (0.41) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL7592460 0.85 SLC29A1 (0.46) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL7119645 0.84 CYP2C19 (0.38) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A
SCHEMBL6837777 0.84 NSD3 (0.40) CYP2C19CYP1A2CYP3A4CYP2C9HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0919562-B1 PHOSPHONATE NUCLEOTIDE COMPOUNDS MITSUBISHI CHEM CORP (JP) 2002-11-06 EP disclosed
US-6194398-B1 VIRICIDES AGAINST HUMAN IMMUNODEFICIENCY VIRUS, HERPES SIMPLEX VIRUS, HEPATITIS B VIRUS; ANTITUMOR AGENTS; SIDE EFFECT REDUCTION; ORAL ABSORPTION BIOAVAILABILITY; A 2-AMINO-6-HYDROCARBYLTHIO-9-(2-(PHOSPHONOMETHOXY)ETHYL-9H-PURINE MITSUBISHI CHEMICAL CORPORATION (JP) 2001-02-27 US disclosed
EP-0919562-A1 PHOSPHONATE NUCLEOTIDE COMPOUNDS MITSUBISHI CHEMICAL CORPORATION (JP) 1999-06-02 EP disclosed