Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 3/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.55 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9352124 | 1.00 | SRD5A1 (0.57) | SRD5A1SRD5A2AR | |
| SCHEMBL8721495 | 1.00 | SRD5A1 (0.57) | SRD5A1SRD5A2AR | |
| SCHEMBL5007912 | 1.00 | SRD5A1 (0.57) | SRD5A1SRD5A2AR | |
| SCHEMBL5007914 | 1.00 | SRD5A1 (0.57) | SRD5A1SRD5A2AR | |
| SCHEMBL7788657 | 0.84 | CDK5 (0.45) | SRD5A1SRD5A2 | |
| SCHEMBL7788660 | 0.84 | CDK5 (0.45) | SRD5A1SRD5A2 | |
| SCHEMBL15549711 | 0.81 | SRD5A2 (0.53) | SRD5A1SRD5A2AR | |
| SCHEMBL9393886 | 0.80 | CDK5 (0.44) | SRD5A1 | |
| SCHEMBL1948752 | 0.80 | SRD5A2 (0.54) | SRD5A1SRD5A2AR | |
| SCHEMBL8134829 | 0.80 | SRD5A2 (0.54) | SRD5A1SRD5A2AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922770-B1 | A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase | POLI IND CHIMICA SPA (IT) | 2002-09-18 | — | — | EP | disclosed |
| EP-0649306-B1 | ESTER DERIVATIVES OF 4-AZA-STEROIDS | MERCK & CO INC (US) | 2001-01-10 | — | — | EP | disclosed |
| EP-0641204-B1 | 17-ETHERS AND THIOETHERS OF 4-AZA-STEROIDS | MERCK & CO INC (US) | 2000-08-16 | — | — | EP | disclosed |
| EP-0786011-B1 | Microbiological process for the preparation of 1-unsaturated 17-beta-carboxysubstituted 3-oxo-4-azaandrostan-3-ones | POLI IND CHIMICA SPA (IT) | 2000-04-05 | — | — | EP | disclosed |
| EP-0786011-B1 | Microbiological process for the preparation of 1-unsaturated 17-beta-carboxysubstituted 3-oxo-4-azaandrostan-3-ones | POLI IND CHIMICA SPA (IT) | 2000-04-05 | — | — | EP | disclosed |
| EP-0922770-A3 | A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1999-06-30 | — | — | EP | disclosed |
| EP-0922770-A2 | A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1999-06-16 | — | — | EP | disclosed |
| EP-0922770-A2 | A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1999-06-16 | — | — | EP | disclosed |
| US-5693809-A | PREGNANES FOR TREATING ALOPECIA, ACNE AND SKIN DISORDER | MERCK & CO., INC. (US) | 1997-12-02 | — | — | US | disclosed |
| EP-0786011-A1 | A MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF 17BETA-CARBOXY SUBSTITUTED 3-OXO-4-AZASTEROIDS AND THE USE OF SUCH PRODUCTS AS INHIBITORS OF THE ENZYME 5ALPHA-REDUCTASE | POLI INDUSTRIA CHIMICA S.p.A. (IT) | 1997-07-30 | — | — | EP | disclosed |
| EP-0649306-A4 | ESTER DERIVATIVES OF 4-AZA-STEROIDS. | MERCK & CO INC (US) | 1995-08-23 | — | — | EP | disclosed |
| EP-0649431-A4 | 17-AMINO SUBSTITUTED 4-AZASTEROID 5-G(A)-REDUCTASE INHIBITORS. | — | 1995-05-03 | — | — | EP | disclosed |
| EP-0649306-A1 | ESTER DERIVATIVES OF 4-AZA-STEROIDS | MERCK & CO. INC. (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0649431-A1 | 17-AMINO SUBSTITUTED 4-AZASTEROID 5$g(a)-REDUCTASE INHIBITORS | MERCK & CO. INC. (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0641204-A1 | 17-ETHERS AND THIOETHERS OF 4-AZA-STEROIDS | MERCK & CO. INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0641211-A1 | INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY | ENDORECHERCHE INC. (CA) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023040-A1 | 17-ETHERS AND THIOETHERS OF 4-AZA-STEROIDS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| WO-1993023053-A1 | INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY | ENDORECHERCHE INC. (CA) | 1993-11-25 | — | — | WO | disclosed |
| WO-1993023039-A1 | SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| WO-1993023041-A1 | ESTER DERIVATIVES OF 4-AZA-STEROIDS | MERCK & CO., INC. (US) | 1993-11-25 | — | — | WO | disclosed |