Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 15/20 | 0.68 |
| ▸ | CCR3 | P51677 | 2/20 | 0.68 |
| ▸ | DRD2 | P14416 | 5/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6396151 | 0.99 | DRD4 (0.67) | DRD4CCR3DRD2CYP1A2CYP3A4 | |
| Isobutyramide SCHEMBL27550765 | 0.93 | CCR3 (0.60) | DRD4CCR3DRD2CYP1A2CYP3A4 | |
| SCHEMBL6396896 | 0.87 | KMT2A (0.65) | CCR3MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL27570386 | 0.85 | CCR3 (0.74) | DRD4CCR3DRD2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL27570348 | 0.81 | CCR3 (0.71) | DRD4CCR3DRD2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6402140 | 0.81 | CCR3 (0.71) | DRD4CCR3DRD2CYP1A2CYP3A4 | |
| SCHEMBL5658825 | 0.81 | CCR3 (1.00) | DRD4CCR3DRD2CYP1A2CYP3A4 | |
| Hydrochloric Acid SCHEMBL6399917 | 0.80 | CCR3 (0.98) | DRD4CCR3DRD2CYP1A2CYP3A4 | |
| SCHEMBL1322020 | 0.79 | DRD4 (1.00) | DRD4DRD2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6399874 | 0.79 | HPGD (0.57) | CCR3MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165545-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000058305-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-10-05 | — | — | WO | disclosed |