Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | PREP | P48147 | 3/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7598366 | 1.00 | TMEM97 (0.51) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL1841001 | 1.00 | TMEM97 (0.51) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL16414618 | 0.96 | PREP (0.54) | PREPSMN1; SMN2NPC1RAB9AACE2 | |
| SCHEMBL1842266 | 0.93 | TMEM97 (0.54) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL3605585 | 0.90 | SPHK2 (0.54) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL1190565 | 0.90 | SPHK2 (0.54) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL80752 | 0.90 | SPHK2 (0.54) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL19621551 | 0.89 | TMEM97 (0.56) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL14646665 | 0.89 | TMEM97 (0.56) | TMEM97SIGMAR1PREPFKBP1ASMN1; SMN2 | |
| SCHEMBL10772392 | 0.89 | PREP (0.52) | TMEM97SIGMAR1PREPSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5917034-A | Antithrombotic n-amidinopiperidine and benzamidine derivatives | PFIZER INC. (US) | 1999-06-29 | — | — | US | disclosed |
| EP-0858458-A1 | ANTITHROMBOTIC N-AMIDINOPIPERIDINE AND BENZAMIDINE DERIVATIVES | Pfizer Limited (GB) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997016444-A1 | ANTITHROMBOTIC N-AMIDINOPIPERIDINE AND BENZAMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 1997-05-09 | — | — | WO | disclosed |