Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.63 |
| ▸ | EDNRA | P25101 | 5/20 | 0.63 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | DHPS | P49366 | 1/20 | 0.52 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.52 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595558 | 0.92 | EDNRA (0.68) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7586212 | 0.91 | EDNRB (0.54) | EDNRBEDNRA | |
| SCHEMBL7949161 | 0.90 | EDNRB (0.68) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7593718 | 0.86 | EDNRA (0.73) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7598400 | 0.86 | EDNRA (0.62) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7596644 | 0.85 | EDNRA (0.57) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7599581 | 0.82 | EDNRA (0.65) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7584814 | 0.81 | EDNRA (0.80) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7598423 | 0.81 | EDNRA (0.78) | EDNRBEDNRAABCC3ABCC4NR1I2 | |
| SCHEMBL7600949 | 0.81 | EDNRA (0.79) | EDNRBEDNRAABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768304-B1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | HOFFMANN LA ROCHE (CH) | 2002-05-22 | — | — | EP | disclosed |
| EP-0768304-A1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1997-04-16 | — | — | EP | disclosed |