Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8397158 | 0.91 | EDNRA (0.49) | EDNRAEDNRB | |
| SCHEMBL7590654 | 0.90 | EDNRA (0.53) | EDNRAEDNRB | |
| SCHEMBL7598561 | 0.89 | EDNRA (0.50) | EDNRAEDNRB | |
| SCHEMBL7586113 | 0.89 | EDNRA (0.46) | EDNRAEDNRB | |
| SCHEMBL7949146 | 0.89 | EDNRA (0.46) | EDNRAEDNRB | |
| SCHEMBL7589737 | 0.85 | EDNRA (0.62) | EDNRAEDNRB | |
| SCHEMBL7591508 | 0.83 | EDNRA (0.54) | EDNRAEDNRB | |
| SCHEMBL7586114 | 0.82 | EDNRA (0.75) | EDNRAEDNRB | |
| SCHEMBL8395136 | 0.81 | EDNRA (0.51) | EDNRAEDNRB | |
| SCHEMBL7596071 | 0.79 | EDNRA (0.52) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5856484-A | Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | claimed |
| EP-0768304-B1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | HOFFMANN LA ROCHE (CH) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001049289-A1 | PHARMACEUTICAL AND VETERINARY USES OF ENDOTHELIN ANTAGONISTS | TEXAS BIOTECHNOLOGY CORPORATION (US) | 2001-07-12 | — | — | WO | disclosed |
| US-5856484-A | Sulfonylaminopyrimidine carboxylic acid derivatives having endothelin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 1999-01-05 | — | — | US | disclosed |
| EP-0768304-A1 | N-(Pyrimidinyl)-benzenesulfonamides as medicaments | F. HOFFMANN-LA ROCHE AG (CH) | 1997-04-16 | — | — | EP | disclosed |