Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.66 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | DRD1 | P21728 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592205 | 0.89 | PRCP (0.62) | PRCPSLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL6257081 | 0.89 | PRCP (0.62) | PRCPSLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL29783569 | 0.84 | PRCP (0.77) | PRCPCHRM3TRPM8DRD2DRD1 | |
| SCHEMBL22784853 | 0.84 | PRCP (0.77) | PRCPCHRM3TRPM8DRD2DRD1 | |
| SCHEMBL30965968 | 0.84 | PRCP (0.77) | PRCPCHRM3TRPM8DRD2DRD1 | |
| SCHEMBL5245455 | 0.84 | PRCP (0.77) | PRCPCHRM3TRPM8DRD2DRD1 | |
| SCHEMBL7584352 | 0.82 | PRCP (0.69) | PRCPSLC6A4MEN1CYP3A4KMT2A | |
| SCHEMBL29783566 | 0.81 | PRCP (0.77) | PRCPSLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL5244522 | 0.81 | PRCP (0.77) | PRCPSLC6A2SLC6A4SLC6A3CHRM3 | |
| SCHEMBL6253578 | 0.80 | SLC6A2 (0.51) | PRCPSLC6A2SLC6A4SLC6A3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246805-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | ALBANY MOLECULAR RESEARCH, INC. (US) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001032624-A1 | 4-PHENYL-SUBSTITUTED TETRAHYDROISOQUINOLINES AND USE THEREOF TO BLOCK REUPTAKE OF NOREPINEPHRINE, DOPAMINE AND SEROTONIN | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-05-10 | — | — | WO | disclosed |