Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 12/20 | 0.75 |
| ▸ | JAK2 | O60674 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.59 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.49 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.49 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.49 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.49 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.49 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.49 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.49 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.45 |
| ▸ | IDH1 | O75874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7017487 | 1.00 | LCK (0.75) | LCKJAK2JAK3ATP1A1ATP1B1 | |
| SCHEMBL7026126 | 0.94 | LCK (0.82) | LCKJAK2JAK3ATP1A1ATP1B1 | |
| SCHEMBL7587969 | 0.90 | LCK (0.74) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7020598 | 0.90 | LCK (0.74) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7020879 | 0.89 | LCK (0.90) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7592779 | 0.86 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7016875 | 0.86 | LCK (1.00) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7021150 | 0.86 | LCK (0.85) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7588541 | 0.85 | LCK (0.77) | LCKJAK2JAK3MKNK1MKNK2 | |
| SCHEMBL7018966 | 0.85 | LCK (0.77) | LCKJAK2JAK3MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206265-A4 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO INC (US) | 2002-08-07 | — | — | EP | disclosed |
| EP-1206265-A1 | SRC KINASE INHIBITOR COMPOUNDS | Merck & Co., Inc. (US) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001000213-A1 | SRC KINASE INHIBITOR COMPOUNDS | MERCK & CO., INC. (US) | 2001-01-04 | — | — | WO | disclosed |