Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.54 |
| ▸ | ADORA2B | P29275 | 7/20 | 0.54 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6835030 | 1.00 | ADORA2A (0.55) | ADORA2AADORA3ADORA2BADORA1CDK1 | |
| SCHEMBL6841625 | 0.93 | ADORA2A (0.56) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7601344 | 0.89 | ADORA2A (0.56) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7601339 | 0.89 | ADORA2A (0.56) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6839238 | 0.89 | ADORA2A (0.56) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6841744 | 0.88 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7597473 | 0.88 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7597469 | 0.88 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7596392 | 0.88 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL7596397 | 0.88 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051425-B1 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-10-30 | — | — | EP | claimed |