Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | TSPO | P30536 | 1/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | TACR3 | P29371 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781008 | 0.96 | ABCG2 (0.57) | ABCG2ADORA3ABCC1MEN1KMT2A | |
| Dimethylamine SCHEMBL4104002 | 0.90 | ABCG2 (0.55) | ABCG2ADORA3ABCC1MEN1KMT2A | |
| SCHEMBL16039146 | 0.88 | CYP1A1 (0.60) | ABCG2ADORA3MEN1KMT2AALDH1A1 | |
| SCHEMBL16039656 | 0.88 | MAPT (0.59) | ABCG2ADORA3ABCC1MEN1KMT2A | |
| SCHEMBL5795510 | 0.88 | CYP1B1 (0.60) | ABCG2ADORA3ABCC1MEN1KMT2A | |
| SCHEMBL16038378 | 0.88 | PDE10A (0.58) | ABCG2ADORA3ABCC1MEN1KMT2A | |
| SCHEMBL16039130 | 0.88 | MEN1 (0.62) | ABCG2ADORA3ABCC1MEN1KMT2A | |
| SCHEMBL15253806 | 0.85 | ABCG2 (0.57) | ABCG2ADORA3ABCC1MEN1KMT2A | |
| SCHEMBL10727060 | 0.85 | ABCG2 (0.50) | ABCG2ADORA3ABCC1DHODHMEN1 | |
| SCHEMBL16039610 | 0.84 | PRNP (0.47) | ABCG2ADORA3ABCC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4639454-A | LYMPHOID LEUKEMIA | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-01-27 | — | — | US | claimed |
| US-20020156050-A1 | Carboxamine compounds, methods and compositions for inhibiting PARP activity | GUILFORD PHARMACEUTICALS INC. | 2002-10-24 | — | — | US | disclosed |
| US-6395749-B1 | Carboxamide compounds, methods, and compositions for inhibiting PARP activity | GUILFORD PHARMACEUTICALS INC. | 2002-05-28 | — | — | US | disclosed |
| US-4639454-A | LYMPHOID LEUKEMIA | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| US-4639454-A | LYMPHOID LEUKEMIA | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020156050-A1 | Carboxamine compounds, methods and compositions for inhibiting PARP activity | PARP1, PARP3, PARP4 | ABCG2 146/4885ADORA3 909/4885ABCC1 1538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.