Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 10/20 | 0.48 |
| ▸ | CA1 | P00915 | 9/20 | 0.48 |
| ▸ | CA12 | O43570 | 7/20 | 0.48 |
| ▸ | CA9 | Q16790 | 7/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.47 |
| ▸ | F10 | P00742 | 4/20 | 0.47 |
| ▸ | PLAU | P00749 | 3/20 | 0.45 |
| ▸ | F2 | P00734 | 2/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HPN | P05981 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7600451 | 0.94 | F10 (0.52) | CA2CA1CA12CA9PRSS1 | |
| SCHEMBL7118692 | 0.91 | PLAU (0.48) | CA2CA1CA12CA9PRSS1 | |
| SCHEMBL7600785 | 0.90 | CA1 (0.55) | CA2CA1CA12CA9PRSS1 | |
| SCHEMBL7600245 | 0.83 | F10 (0.53) | CA2CA1CA12CA9PRSS1 | |
| SCHEMBL7114682 | 0.82 | F10 (0.68) | CA2CA1CA12CA9PRSS1 | |
| SCHEMBL7600812 | 0.81 | F10 (0.72) | PRSS1F10PLG | |
| SCHEMBL7008413 | 0.78 | F10 (0.64) | PRSS1F10F2 | |
| SCHEMBL6298111 | 0.74 | PRSS1 (0.51) | PRSS1F10F2PLG | |
| SCHEMBL7601136 | 0.73 | F10 (0.58) | PRSS1F10F2PLGPLAT | |
| SCHEMBL7597733 | 0.71 | F10 (0.73) | PRSS1F10PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257530-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-11-20 | — | — | EP | claimed |
| WO-2001062717-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-08-30 | — | — | WO | claimed |
| EP-1257530-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001062717-A1 | AMINOSULFONYLBIPHENYL DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-08-30 | — | — | WO | disclosed |