Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 8/20 | 0.55 |
| ▸ | DRD2 | P14416 | 6/20 | 0.55 |
| ▸ | DRD3 | P35462 | 6/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NCF1 | P14598 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601734 | 1.00 | DRD4 (0.55) | DRD4DRD2DRD3SIGMAR1MC4R | |
| SCHEMBL7601732 | 1.00 | DRD4 (0.55) | DRD4DRD2DRD3SIGMAR1MC4R | |
| SCHEMBL418557 | 0.82 | DRD4 (0.57) | DRD4DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL7408726 | 0.77 | GAA (0.46) | MAPTNPSR1L3MBTL1POLBNCF1 | |
| SCHEMBL24353158 | 0.77 | DRD4 (0.52) | DRD4DRD2DRD3SIGMAR1MAPT | |
| SCHEMBL8131885 | 0.76 | ATM (0.67) | DRD4DRD2DRD3SIGMAR1MC4R | |
| SCHEMBL6864941 | 0.76 | DRD4 (0.81) | DRD4DRD2DRD3SIGMAR1 | |
| SCHEMBL7406857 | 0.76 | GAA (0.49) | MAPTNPSR1L3MBTL1NCF1 | |
| SCHEMBL7419975 | 0.76 | GAA (0.49) | MAPTNPSR1L3MBTL1NCF1 | |
| SCHEMBL12000243 | 0.75 | DRD4 (0.64) | DRD4DRD2DRD3SIGMAR1MC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891344-B1 | ALPHA-1 ADRENERGIC RECEPTOR ANTAGONISTS | SOD CONSEILS RECH APPLIC (FR) | 2002-12-18 | — | — | EP | disclosed |
| US-6300499-B1 | α1-adrenergic receptor antagonists | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2001-10-09 | — | — | US | disclosed |