Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 18/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL760276 | 1.00 | CETP (0.50) | CETPKCNH2LMNAMAPTKMT2A | |
| SCHEMBL759367 | 0.93 | CETP (0.52) | CETPKCNH2 | |
| SCHEMBL760397 | 0.93 | CETP (0.52) | CETPKCNH2 | |
| SCHEMBL758321 | 0.91 | CETP (0.54) | CETPKCNH2 | |
| SCHEMBL759071 | 0.91 | CETP (0.54) | CETPKCNH2 | |
| SCHEMBL14297837 | 0.90 | CETP (0.49) | CETPKCNH2 | |
| SCHEMBL758504 | 0.90 | CETP (0.52) | CETPKCNH2 | |
| SCHEMBL758505 | 0.90 | CETP (0.52) | CETPKCNH2 | |
| SCHEMBL14297766 | 0.88 | CETP (0.49) | CETPKCNH2 | |
| SCHEMBL760794 | 0.87 | CETP (0.53) | CETPKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-B9 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-1954668-B1 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-09-28 | — | — | EP | disclosed |